Publications

Production 1

Redox Immunology

Publications examining reactive oxygen species, redox-sensitive immune signaling, inflammatory activation, and redox-based strategies in type 1 diabetes.

Research Article

Reactive oxygen species are required for driving efficient and sustained aerobic glycolysis during CD4+ T cell activation

Previte DM, O'Connor EC, Novak EA, Martins CP, Mollen KP, Piganelli JD

PLOS ONE · 2017

DOI: 10.1371/journal.pone.0175549 ↗

Review

Reactive Oxygen Species and Their Implications on CD4+ T Cells in Type 1 Diabetes

Previte DM, Piganelli JD

Antioxidants & Redox Signaling · 2018

DOI: 10.1089/ars.2017.7357 ↗

Research Article

Disruption of innate-mediated proinflammatory cytokine and reactive oxygen species third signal leads to antigen-specific hyporesponsiveness

Tse HM, Milton MJ, Schreiner S, Profozich JL, Trucco M, Piganelli JD

The Journal of Immunology · 2007

DOI: 10.4049/jimmunol.178.2.908 ↗

Research Article

A Metalloporphyrin-Based Superoxide Dismutase Mimic Inhibits Adoptive Transfer of Autoimmune Diabetes by a Diabetogenic T-Cell Clone

Piganelli JD et al.

Diabetes · 2002

DOI: 10.2337/diabetes.51.2.347 ↗

Production 2

T Cell Metabolism

Publications defining the metabolic requirements of autoreactive T cells and exploring immunometabolism as a therapeutic vulnerability in autoimmunity.

Research Article

Glycolysis Inhibition Induces Functional and Metabolic Exhaustion of CD4+ T Cells in Type 1 Diabetes

Martins CP, New LA, O'Connor EC, Previte DM, Cargill KR, Tse IL, Sims-Lucas S, Piganelli JD

Frontiers in Immunology · 2021

DOI: 10.3389/fimmu.2021.669456 ↗

Research Article

Reactive oxygen species are required for driving efficient and sustained aerobic glycolysis during CD4+ T cell activation

Previte DM, O'Connor EC, Novak EA, Martins CP, Mollen KP, Piganelli JD

PLOS ONE · 2017

DOI: 10.1371/journal.pone.0175549 ↗

Review

Targeting T cell Metabolism to Combat Autoimmunity: Implications for the Future of Type 1 Diabetes Therapeutics

Martins CP, Piganelli JD

Immunometabolism · 2020

DOI: 10.20900/immunometab20200010 ↗

Production 3

Beta Cell Stress

Publications connecting endoplasmic reticulum stress, autophagy, inflammatory stress, neo-epitope formation, and increased beta cell immune visibility.

Research Article

Dysfunctional β-cell autophagy induces β-cell stress and enhances islet immunogenicity

Austin MC, Muralidharan C, Roy S, Crowder JJ, Piganelli JD, Linnemann AK

Frontiers in Immunology · 2025

DOI: 10.3389/fimmu.2025.1504583 ↗

Review

The Role of β Cell Stress and Neo-Epitopes in the Immunopathology of Type 1 Diabetes

Piganelli JD, Mamula MJ, James EA

Frontiers in Endocrinology · 2021

DOI: 10.3389/fendo.2020.624590 ↗

Review

Environmental Factors Contribute to β Cell Endoplasmic Reticulum Stress and Neo-Antigen Formation in Type 1 Diabetes

Marré ML, Piganelli JD

Frontiers in Endocrinology · 2017

DOI: 10.3389/fendo.2017.00262 ↗

Review

β cell ER stress and the implications for immunogenicity in type 1 diabetes

Marré ML, James EA, Piganelli JD

Frontiers in Cell and Developmental Biology · 2015

DOI: 10.3389/fcell.2015.00067 ↗

Production 4

Early Biomarkers

Publications focused on detecting immune activation and disease-relevant biology before or during early stages of type 1 diabetes progression.

Preprint

Soluble LAG-3 Identifies a Dynamic Early T Cell Activation Window in self-reactivity, Type 1 Diabetes, and Broader Immune Responses

Roy S, Proffer ML, Syed F, Smithmyer ME, Das Sharma A, Twoy A, Soo-Hoo E, Rana J, Spaeth JM, Meyer E, Jensen KP, Speake C, Hagopian W, Piganelli JD

bioRxiv · 2026

DOI: 10.64898/2026.02.10.705171 ↗

Production 5

Antigen-Specific T Cells

Publications using antigen-specific T cell systems to dissect activation, tolerance, diabetogenic function, and autoimmune progression.

Preprint

Soluble LAG-3 Identifies a Dynamic Early T Cell Activation Window in self-reactivity, Type 1 Diabetes, and Broader Immune Responses

Roy S et al.

bioRxiv · 2026

DOI: 10.64898/2026.02.10.705171 ↗

Research Article

Disruption of innate-mediated proinflammatory cytokine and reactive oxygen species third signal leads to antigen-specific hyporesponsiveness

Tse HM, Milton MJ, Schreiner S, Profozich JL, Trucco M, Piganelli JD

The Journal of Immunology · 2007

DOI: 10.4049/jimmunol.178.2.908 ↗

Methods

Generation, maintenance, and adoptive transfer of diabetogenic T-cell lines/clones from the nonobese diabetic mouse

Milton MJ, Poulin M, Mathews C, Piganelli JD

Methods in Molecular Medicine · 2004

DOI: 10.1385/1-59259-805-6:213 ↗

Research Article

A Metalloporphyrin-Based Superoxide Dismutase Mimic Inhibits Adoptive Transfer of Autoimmune Diabetes by a Diabetogenic T-Cell Clone

Piganelli JD et al.

Diabetes · 2002

DOI: 10.2337/diabetes.51.2.347 ↗

Production 6

Translational Models

Publications testing interventions, human islet biology, adoptive-transfer models, transplantation, and other systems that bridge mechanism with translational application.

Research Article

Glycolysis Inhibition Induces Functional and Metabolic Exhaustion of CD4+ T Cells in Type 1 Diabetes

Martins CP et al.

Frontiers in Immunology · 2021

DOI: 10.3389/fimmu.2021.669456 ↗

Research Article

Redox modulation protects islets from transplant-related injury

Sklavos MM et al.

Diabetes · 2010

DOI: 10.2337/db09-0588 ↗

Research Article

Response of human islets to isolation stress and the effect of antioxidant treatment

Bottino R, Balamurugan AN, Tse H, et al., Piganelli JD

Diabetes · 2004

DOI: 10.2337/diabetes.53.10.2559 ↗

Research Article

Preservation of Human Islet Cell Functional Mass by Anti-Oxidative Action of a Novel SOD Mimic Compound

Piganelli JD and collaborators

Diabetes · 2002

DOI: 10.2337/diabetes.51.8.2561 ↗

Research Article

Dysfunctional β-cell autophagy induces β-cell stress and enhances islet immunogenicity

Austin MC, Muralidharan C, Roy S, Crowder JJ, Piganelli JD, Linnemann AK

Frontiers in Immunology · 2025

DOI: 10.3389/fimmu.2025.1504583 ↗

Redox Immunology

Reactive oxygen species are required for driving efficient and sustained aerobic glycolysis during CD4+ T cell activation

Reactive Oxygen Species and Their Implications on CD4+ T Cells in Type 1 Diabetes

Disruption of innate-mediated proinflammatory cytokine and reactive oxygen species third signal leads to antigen-specific hyporesponsiveness

A Metalloporphyrin-Based Superoxide Dismutase Mimic Inhibits Adoptive Transfer of Autoimmune Diabetes by a Diabetogenic T-Cell Clone

T Cell Metabolism

Glycolysis Inhibition Induces Functional and Metabolic Exhaustion of CD4+ T Cells in Type 1 Diabetes

Reactive oxygen species are required for driving efficient and sustained aerobic glycolysis during CD4+ T cell activation

Targeting T cell Metabolism to Combat Autoimmunity: Implications for the Future of Type 1 Diabetes Therapeutics

Beta Cell Stress

Dysfunctional β-cell autophagy induces β-cell stress and enhances islet immunogenicity

The Role of β Cell Stress and Neo-Epitopes in the Immunopathology of Type 1 Diabetes

Environmental Factors Contribute to β Cell Endoplasmic Reticulum Stress and Neo-Antigen Formation in Type 1 Diabetes

β cell ER stress and the implications for immunogenicity in type 1 diabetes

Early Biomarkers

Soluble LAG-3 Identifies a Dynamic Early T Cell Activation Window in self-reactivity, Type 1 Diabetes, and Broader Immune Responses

Antigen-Specific T Cells

Soluble LAG-3 Identifies a Dynamic Early T Cell Activation Window in self-reactivity, Type 1 Diabetes, and Broader Immune Responses

Disruption of innate-mediated proinflammatory cytokine and reactive oxygen species third signal leads to antigen-specific hyporesponsiveness

Generation, maintenance, and adoptive transfer of diabetogenic T-cell lines/clones from the nonobese diabetic mouse

A Metalloporphyrin-Based Superoxide Dismutase Mimic Inhibits Adoptive Transfer of Autoimmune Diabetes by a Diabetogenic T-Cell Clone

Translational Models

Glycolysis Inhibition Induces Functional and Metabolic Exhaustion of CD4+ T Cells in Type 1 Diabetes

Redox modulation protects islets from transplant-related injury

Response of human islets to isolation stress and the effect of antioxidant treatment

Preservation of Human Islet Cell Functional Mass by Anti-Oxidative Action of a Novel SOD Mimic Compound

Dysfunctional β-cell autophagy induces β-cell stress and enhances islet immunogenicity

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